Antibiotic Resistance in Dermatology Part 1: Mechanisms of Resistance

Abstract and Introduction

Abstract

Virtually any antibiotic can be used in dermatology given the broad range of conditions treated. With the widespread use of antibiotics and the rapid emergence of resistant organisms, it is important to understand the mechanisms at play that contribute to resistance.

Introduction

The advent of antibiotics is arguably one of the greatest achievements in history, permitting survival among many with infections who would have previously died without intervention. Amid the fields in which the use of antibiotics is particularly widespread lies dermatology. A spectrum of inflammatory and infectious dermatologic conditions have been treated with antibiotics since their inception. The continued success of any therapeutic agent is compromised by the potential development of tolerance or resistance to that compound over time.^[1] In the case of antibiotics, resistance among bacteria has become a serious issue and has been named one of the greatest threats to human health.^[2] The number of infections caused by multidrug-resistant bacteria is increasing, and the specter of untreatable infections is now a reality.^[2] As this number increases, new antibiotic developments cannot match the pace.^[2]

While many factors contribute to the development of resistance, its basis stems from bacterial alterations at the molecular level. Therefore, it is important for dermatologists to understand the mechanisms at play.

Skin Therapy Letter. 2023;28(1):7-10. © 2023 SkinCareGuide.com