COVID-19 Bivalent Booster Vaccination Coverage and Intent to Receive Booster Vaccination Among Adolescents and Adults

United States, November-December 2022

Peng-jun Lu, MD, PhD; Tianyi Zhou, MPH; Tammy A. Santibanez, PhD; Anurag Jain, MS; Carla L. Black, PhD; Anup Srivastav, PhD; Mei-Chuan Hung, PhD; Jennifer L. Kriss, PhD; Susanne Schorpp, PhD; David Yankey, PhD; Natalie Sterrett, MPH; Hannah E. Fast, MPH; Hilda Razzaghi, PhD; Laurie D. Elam-Evans, PhD; James A. Singleton, PhD

Disclosures

Morbidity and Mortality Weekly Report. 2023;72(7):190-198. 

In This Article

Abstract and Introduction

Introduction

COVID-19 vaccine booster doses are safe and maintain protection after receipt of a primary vaccination series and reduce the risk for serious COVID-19–related outcomes, including emergency department visits, hospitalization, and death.[1,2] CDC recommended an updated (bivalent) booster for adolescents aged 12–17 years and adults aged ≥18 years on September 1, 2022.[3] The bivalent booster is formulated to protect against the Omicron BA.4 and BA.5 subvariants of SARS-CoV-2 as well as the original (ancestral) strain.[3] Based on data collected during October 30–December 31, 2022, from the National Immunization Survey–Child COVID Module (NIS-CCM),[4] among all adolescents aged 12–17 years who completed a primary series, 18.5% had received a bivalent booster dose, 52.0% had not yet received a bivalent booster but had parents open to booster vaccination for their child, 15.1% had not received a bivalent booster and had parents who were unsure about getting a booster vaccination for their child, and 14.4% had parents who were reluctant to seek booster vaccination for their child. Based on data collected during October 30–December 31, 2022, from the National Immunization Survey–Adult COVID Module (NIS-ACM),[4] 27.1% of adults who had completed a COVID-19 primary series had received a bivalent booster, 39.4% had not yet received a bivalent booster but were open to receiving booster vaccination, 12.4% had not yet received a bivalent booster and were unsure about getting a booster vaccination, and 21.1% were reluctant to receive a booster. Adolescents and adults in rural areas had a much lower primary series completion rate and up-to-date vaccination coverage. Bivalent booster coverage was lower among non-Hispanic Black or African American (Black) and Hispanic or Latino (Hispanic) adolescents and adults compared with non-Hispanic White (White) adolescents and adults. Among adults who were open to receiving booster vaccination, 58.9% reported not having received a provider recommendation for booster vaccination, 16.9% had safety concerns, and 4.4% reported difficulty getting a booster vaccine. Among adolescents with parents who were open to getting a booster vaccination for their child, 32.4% had not received a provider recommendation for any COVID-19 vaccination, and 11.8% had parents who reported safety concerns. Although bivalent booster vaccination coverage among adults differed by factors such as income, health insurance status, and social vulnerability index (SVI), these factors were not associated with differences in reluctance to seek booster vaccination. Health care provider recommendations for COVID-19 vaccination; dissemination of information by trusted messengers about the continued risk for COVID-19–related illness and the benefits and safety of bivalent booster vaccination; and reducing barriers to vaccination could improve COVID-19 bivalent booster coverage among adolescents and adults.

NIS-CCM and NIS-ACM data were collected by telephone interview in English, Spanish, or other languages using a random-digit–dialed sample of cellular telephone numbers. Data collected during October 30–December 31, 2022,* were analyzed to assess demographic, behavioral, and social factors associated with COVID-19 primary series vaccination,†,§,¶ bivalent booster receipt,**,††,§§ up-to-date COVID-19 vaccination status,¶¶ and, among adults or their children who had not received a bivalent booster dose, intent to receive booster vaccination or to get their child a booster vaccination. Receipt of an updated bivalent booster was not explicitly asked of respondents; however, only bivalent boosters were authorized after September 1, 2022.[3] Thus, a booster vaccination received after September 1, 2022, was assumed to be a bivalent booster. The cumulative NIS-CCM and NIS-ACM response rates as of December 2022 were 18.2% and 23.2%, respectively. Bivalent booster dose receipt and intention to receive (or have child receive) a booster dose were assessed among the subset of respondents who had completed the primary COVID-19 vaccination series[5] (2,900 [NIS-CCM]; 83,462 [NIS-ACM]). Primary series completion and up-to-date COVID-19 vaccination status were assessed among all adolescents (4,383 [NIS-CCM]) and adults (99,056 [NIS-ACM]).

Primary series completion, up-to-date COVID-19 vaccination status, bivalent booster vaccination status, and intention to receive (or have one's child receive) a booster were stratified by race and ethnicity,*** metropolitan statistical area (MSA),††† SVI,§§§ other demographic characteristics, and behavioral and social drivers of vaccination.[6] Persons considered open to booster vaccination included those who reported they definitely or probably would get booster vaccination for themselves or their child. Persons considered reluctant to receive booster vaccination included those who reported they probably or definitely would not get a booster for themselves or their child. Data were analyzed using SAS (version 9.4; SAS Institute) and SUDAAN (version 11.0.1; Research Triangle Institute). All percentages were weighted to represent the noninstitutionalized U.S. adolescent or adult population.¶¶¶ T-tests were used to determine differences between groups with p<0.05 considered statistically significant. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.****

From interviews conducted during November–December 2022, 58.3% of all adolescents aged 12–17 years had completed a COVID-19 vaccine primary series, and 10.7% were up to date with COVID-19 vaccination (Table 1). Among adolescents who had completed a COVID-19 primary series, 18.5% had received a bivalent booster since September 1, 2022; 52.0% had not received a bivalent booster but had parents who were open to booster vaccination for their child (31.0% definitely would and 21.0% probably would), 15.1% had parents who were unsure about getting a booster vaccination for their child, and 14.4% of adolescents had parents who were reluctant to get a booster vaccination for their child. Up-to-date COVID-19 vaccination status among all adolescents, and bivalent booster coverage among those who had completed the primary series, increased from November (9.2% and 15.7%, respectively) to December (12.3% and 21.3%, respectively). COVID-19 primary series completion was similar among Black and White adolescents and higher among Hispanic and non-Hispanic Asian (Asian) adolescents compared with White adolescents, while bivalent booster coverage was lower among Black (10.2%), Hispanic (14.6%), and non-Hispanic other or multiracial adolescents (14.0%) than among White (22.9%) adolescents. Adolescents who were uninsured and those living in a high SVI county had lower bivalent booster coverage compared with those who were insured and living in lower SVI counties. Reluctance to seek child's booster vaccination was lower among Hispanic compared with White adolescents' parents; however, reluctance to seek booster vaccination did not differ by insurance or SVI status. Adolescents in rural (non-MSA) areas had lower COVID-19 vaccine primary series completion rate and up-to-date coverage than those in MSA principal city areas.

Among adults aged ≥18 years interviewed during November–December 2022, 84.2% had completed a COVID-19 primary series, and 23.2% were up to date with COVID-19 vaccination (Table 2). Among adults who had completed a primary COVID-19 vaccination series, 27.1% had received a bivalent booster, 39.4% had not yet received the bivalent booster but reported being open to booster vaccination (23.1% definitely would and 16.3% probably would), 12.4% were unsure about getting a booster, and 21.1% were reluctant to get a booster. Up-to-date COVID-19 vaccination status among all adults, and bivalent booster coverage among those who had completed a primary series increased from November (21.0% and 24.4%, respectively) to December (25.4% and 29.7%, respectively). Primary COVID-19 vaccination series completion was similar among White, Black, and Hispanic adults and higher among Asian adults than among those of all other races and ethnicities. Bivalent booster dose coverage was lower among Black (21.2%), Hispanic (15.0%), and Asian (25.1%) adults compared with White adults (32.1%). Bivalent booster coverage was higher among adults who had received a provider recommendation for booster vaccination (34.9%) than among those without a provider recommendation (22.2%). Bivalent booster dose coverage among adults who lived below the poverty level, were uninsured, and who lived in a moderate or high SVI county was lower than coverage among their less economically disadvantaged and lower SVI counterparts, although reluctance to seek bivalent booster vaccination generally did not differ by poverty, insurance, or SVI status. Adults in rural (non-MSA) areas had lower COVID-19 vaccine primary series completion rate and up-to-date coverage than those in MSA principal city areas.

Among all adults who had completed a COVID-19 primary series, 5.2% reported difficulty getting a booster vaccine, with a higher percentage of those open to booster vaccination (4.4%) and unsure about booster vaccination (6.6%) reporting difficulty than did those who were already vaccinated (3.6%) (Table 3). The most common barrier reported was difficulty getting an appointment (5.5% of adults). Overall, among all adults who had completed a COVID-19 vaccine primary series, Black, Hispanic, and non-Hispanic American Indian or Alaska Native adults were more likely to report difficulty getting a booster vaccine, and Black and Hispanic adults were less likely to report confidence about COVID-19 vaccination safety and receipt of provider recommendation for booster vaccination compared with White adults (Supplementary Table 1, https://stacks.cdc.gov/view/cdc/124394). Among adults who were open to or unsure about booster vaccination, 41.1% and 28.7%, respectively, received a provider recommendation for booster vaccination (58.9% and 71.3%, respectively, did not receive a provider recommendation), and 83.1% and 54.5% of adults, respectively, were confident about COVID-19 vaccination safety (16.9% and 45.5%, respectively, had safety concerns) (Table 3). Among adolescents with parents who were open to or unsure about booster vaccination for their children, 67.6% and 54.8% of these parents, respectively, received a provider recommendation for any COVID-19 vaccine for their child (32.4% and 45.2% did not receive a provider recommendation), and 88.2% and 54.4% of these adolescents, respectively, had parents who were confident about COVID-19 vaccination safety for their child (11.8% and 45.6%, respectively, had parents with safety concerns). Adults and parents of adolescents overwhelmingly reported that a COVID-19 vaccine is important (54%–98% across bivalent booster vaccination and booster vaccination intent categories). Over one half of adults and parents of adolescents reported that vaccination is important, even among those who were reluctance to seek a booster vaccine.

*Approximates coverage as of November 30, 2022.
COVID-19 vaccination status was based on responses to the questions, "Have you received at least one dose of a COVID-19 vaccine?," "Which brand of COVID-19 vaccine did you receive for your first dose?," "How many doses of a COVID-19 vaccine have you received?," and "During what month and year did you receive your most recent COVID-19 vaccine?"
§For adolescents aged 12–17 years, primary series completion was defined as completion of a 2-dose primary COVID-19 vaccine series.
For adults, primary series completion was defined as receipt of a 2-dose primary mRNA or Novavax COVID-19 vaccine series for adults who are not immunocompromised or receipt of a 3-dose mRNA or Novavax COVID-19 vaccine series for adults who reported being immunocompromised. For respondents whose initial vaccine was Janssen (Johnson & Johnson) vaccine, primary series completion was defined as receipt of a single dose primary vaccine for adults who are not immunocompromised or receipt of 2-dose series for adults who reported being immunocompromised.
**For adolescents aged 12–17 years, bivalent booster dose was defined as, since September 1, 2022, the receipt of at least a third dose of COVID-19 vaccine after completion of a 2-dose primary series.
††For adults, bivalent booster dose was defined as receipt of at least a third dose of COVID-19 vaccine since September 1, 2022, after completion of 2-dose primary mRNA or Novavax vaccine series for adults who are not immunocompromised or at least a fourth dose of the vaccine after completion of a 3-dose mRNA or Novavax vaccine series for adults who reported being immunocompromised.
§§For adults whose initial vaccine was a Janssen vaccine, bivalent booster dose was defined as the receipt of at least a second dose of COVID-19 vaccine since September 1, 2022, for adults who are not immunocompromised or at least a third dose for adults who reported being immunocompromised.
¶¶Up-to-date COVID-19 vaccination status was defined as receipt of a primary COVID-19 vaccination series and ≥1 bivalent booster dose or, among those who had not received a bivalent booster, completion of the most recent COVID-19 vaccine dose (the most recent dose could be a primary dose or a monovalent booster dose) <2 months earlier.
***Those who reported Hispanic ethnicity were classified as Hispanic and could be of any race. For adults, "non-Hispanic other/multiple races" included non-Hispanic adults who reported "other" race or more than one race. For adolescents, "non-Hispanic other/multiple races" included non-Hispanic American Indian or Alaska Native, non-Hispanic Native Hawaiian or other Pacific Islander, and non-Hispanic other or multiple races.
†††Urbanicity status was derived based on the centroid of the zip code of residence, categorized as MSA principal city, MSA nonprincipal city, or non-MSA.
§§§Categorization into an SVI level was based on respondent-reported zip code of residence. https://www.atsdr.cdc.gov/placeandhealth/svi/index.html
¶¶¶Survey weights were also calibrated by age and sex to state-level vaccine administration data reported to CDC by jurisdictions as of the middle of the monthly data collection period. https://covid.cdc.gov/covid-data-tracker/ (Accessed November 29, 2022).
****45 C.F.R. part 46.102(l)(2), 21 C.F.R. part 56; 42 U.S.C. Sect. 241(d); 5 U.S.C. Sect. 552a; 44 U.S.C. Sect. 3501.

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